Van der Eycken E. Multicomponent Reactions...Heterocycles 2022 torrent

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Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step.Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs.
Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and C–H functionalization and multicomponent reactions.
Provides a thorough overview of heterocycles as input in multicomponent reactions
Discusses recent advances in the field of MCR chemistry and progress in the synthesis and functionalization of heterocycles
Demonstrates the use of MCRs to simplify synthetic design and achieve complexity and diversity in novel bioactive molecules
Highlights examples of multicomponent polymerizations, target-oriented synthesis, and applications of MCR in medicinal chemistry
Explains the methodology of using on-resin MCRs to produce heterocycle compounds
Illustrating the key role of MCRs towards heterocycles in natural product synthesis, drug discovery, organic synthesis, and other applications,Multicomponent Reactions towards Heterocycles is required reading for synthetic chemists in academia and industry alike.
Heterocycles as Inputs in MCRs: An Update
Heterocycles and Multicomponent Polymerizations
Multicomponent Reactions in Medicinal Chemistry
Solid-Phase Heterocycle Synthesis Using Multicomponent Reactions
Green Synthesis of Heterocycles Via MCRs
The Use of Flow Chemistry in the Multicomponent Synthesis of Heterocycles
C–H Functionalization as an Imperative Tool Toward Multicomponent Synthesis and Modification of Heterocycles
Multicomponent-Switched Reactions in Synthesis of Heterocycles
Recent Applications of Multicomponent Reactions Toward Heterocyclic Drug Discovery
Multicomponent Syntheses of Heterocycles by Catalytic Generation of Alkynoyl Intermediates
Synthesis of Saturated Heterocycles via Multicomponent Reactions
Multicomponent Reactions and Asymmetric Catalysis
Recent Trends in Metal-catalyzed MCRs Toward Heterocycles