Kleinridders A. Physiological Consequences of Brain Insulin.2023 torrent

Textbook in PDF format

The brain is crucial for the regulation of whole-body metabolism and behavior. The pancreas-derived hormone insulin modulates brain function and affects energy metabolism as well as cognition. This is partially achieved by modulating several types of brain cell populations including those relevant to satiety and reward. Importantly, brains of Alzheimer´s disease patients exhibit a signature of brain insulin resistance with perturbed brain metabolism. This book will cover the basics of insulin signaling in the brain and will describe concepts of insulin resistance, a feature of type 2 diabetes. Moreover insulin´s effect on cognitive function will be pointed out and the association between brain insulin resistance and neurodegenerative diseases discussed. Additionally, potential behavioral and pharmacological concepts which can affect brain insulin signaling will be summarized.
Molecular mechanisms of brain insulin signaling　
Insulin/IGF signaling in early brain development
Insulin signaling modulates neuronal metabolism　
Regulation of glial function by insulin peptides　
Neuroendocrine interactions in the control of glucose- and energy homeostasis
Hypothalamic neuronal circuits are modulated by insulin and impact metabolism　
Insulin and brain reward systems　
The impact of insulin on brain serotonergic system: consequences on diabetes-associated mood disorders
Organ cross-talk regulates (brain) insulin action
Insulin resistance as a risk factor for Alzheimer’s disease　
Brain insulin action in the control of metabolism in humans　
Impact of dietary and exercise interventions on brain insulin action and brain function　
Pharmacological and surgical interventions to improve brain insulin resistance