Tröbinger L. High Precision Anatomy for Magnetoencephalography 2014 torrent

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Magnetoencephalography (MEG) is a non-invasive brain imaging method with high temporal resolution but relatively poor spatial resolution as compared to some other non-invasive techniques. This thesis examines how the spatial resolution of MEG can be improved using new recording paradigms in which the subject’s head position is fixed and known in advance. This is accomplished by using subject-specific head casts made using a combination of structural MRI and 3D printing technology. The resulting high-precision spatial models allow one to make inference at spatial scales of the order of cortical laminae. This thesis outlines the design of the head casts and examines the potential theoretical and empirical advances they offer. Specifically I outline simulation and then empirical investigations showing it is possible to non-invasively distinguish between electrophysiological signals in different layers of the cortex