Passi A. Hyaluronan. Structure, Biology and Biotechnology 2023 torrent

Textbook in PDF format

This book addresses the structural and biological properties of the extracellular matrix component and glycosaminoglycan polymer hyaluronan (or hyaluronic acid, HA). The book discusses various aspects of HA biology, e.g., HA synthesis and degradation, as well as the role of HA in embryogenesis, development, and cell maintenance. The reader will learn about the role of HA in different tissues as well as its biological activities triggered by the interaction with different HA receptors. A closer look is had at the involvement of HA in human pathologies such as cancer, kidney fibrosis and wound healing. Biotechnological and biomedical applications for HA such as scaffold generation and drug delivery, including the novel synthetic sulphated HA are explored. This work will appeal to a wide readership within the extracellular matrix and hyaluronan field. It can serve as an introduction to the field for junior scientists but can also help senior scientists to gain a broader view of the field beyond their area of specialization.
Biochemistry of Hyaluronan Synthesis
Update on Hyaluronan in Development
Long Noncoding RNAs and Epigenetic Regulation of Hyaluronan Synthesis
The Hyaluronan-Rich Zones of Plasma Membrane Protrusions and Extracellular Vesicles
Hyaluronan in Kidney Fibrosis
Inter-α-inhibitor Proteins:​ A Review of Structure and Function
CD44:​ Does CD44v6 Adversely Impact the Prognosis of Cancer Patients?​
The Pharmacokinetics​ and Pharmacodynamics​ of 4-Methylumbellifer​one and its Glucuronide Metabolite in Mice
The Role of Hyaluronan in Skin Wound Healing
Sulfated Hyaluronan:​ A Novel Player in Cancer Therapeutic and Bioengineering Approaches