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Nanoscience has explored new modelling and new devices in the applied sciences and technologies, in health and life sciences. This includes work on structures, nano-machines, communications, environment and materials science, closing the gap for society toward a sustainable civilization. Feynman's Plenty of Room (1959) opened a new perspective/science in society debate: how can we handle the applications––and––implications of nanoscience? What is the human factor in the 21st century?