(reUpload) Coursera - Virology II How Viruses Cause Disease torrent

Virology II How Viruses Cause Disease

Columbia University via Coursera

Overview

This introductory virology course explores the interplay between viruses and their host organisms. The course begins with an overview of how infection is established in a host, then moves to a virologist's view of immune defenses.  Next we consider how the replication strategy and the host response determine the outcome of infection, such that some are short and others are of long duration. The mechanisms by which virus infections transform cells in culture are explored, a process that may lead to tumor formation in animals. We then move to a discussion of how viral infections are controlled by vaccines and antiviral drugs. After an introduction to viral evolution, we discuss the principles learned from zoonotic infections, emerging infections, and humankind's experiences with epidemic and pandemic viral infections. The course ends with an exploration of unusual infectious agents such as viroids, satellites, and prions, followed by a discussion of the causative agent of the most serious current worldwide epidemic, HIV-1.

Syllabus

Week 1
Infection basics
Entry into the host
Viral spread
Tissue invasion and tropism
Transmission and seasonality

Week 2
Innate immune responses
Interferon
Sentinels and complement
Inflammation
Adaptive immunity

Week 3
Viral virulence
Mechanisms of cell injury I
Mechanisms of cell injury II
Host susceptibility

Week 4
Acute infections
Influenza
Poliomyelitis
Measles
Gastroenteritis
West Nile fever

Week 5
Persistent infections
Persistence by modulating the adaptive response
Two persistent infections
Herpes simplex virus
Epstein-Barr virus

Week 6
Transformation
RNA tumor viruses
Transforming retroviruses
DNA tumor viruses
Epiphenomena of a unique life style

Week 7
Vaccines
How do you make a vaccine?
Inactivated vaccines
Attenuated vaccines

Week 8
Antivirals
Antiviral discovery
Antiviral resistance
Other antiviral targets
HIV antivirals

Week 9
Viral evolution
Drivers of evolution
Error threshold and bottlenecks
Selection
Origins of viruses

Week 10
Emerging viruses
Host-virus interactions
Examples of emerging viruses
SARS and MERS
Canine parvovirus

Week 11
Viroids
Satellites
Transmissible spongiform encephalopathies
Prions

Week 12
HIV and AIDS
The origin of HIV
HIV pathogenesis
An amazing but deadly virus
Code:

General
Format : WebM
Format version : Version 2
File size : 47.3 MiB
Duration : 14 min 57 s
Overall bit rate mode : Variable
Overall bit rate : 442 kb/s
Writing application : Lavf55.10.100
Writing library : Lavf55.10.100
FileExtension_Invalid : webm

Video
ID : 1
Format : VP8
Codec ID : V_VP8
Duration : 14 min 57 s
Bit rate : 288 kb/s
Width : 960 pixels
Height : 540 pixels
Display aspect ratio : 16:9
Frame rate mode : Constant
Frame rate : 25.000 FPS
Compression mode : Lossy
Bits/(Pixel*Frame) : 0.022
Stream size : 30.8 MiB (65%)
Language : English
Default : Yes
Forced : No

Audio
ID : 2
Format : Vorbis
Format settings, Floor : 1
Codec ID : A_VORBIS
Duration : 14 min 57 s
Bit rate mode : Variable
Bit rate : 128 kb/s
Maximum bit rate : 700 kb/s
Channel(s) : 2 channels
Sampling rate : 48.0 kHz
Compression mode : Lossy
Delay relative to video : -3 ms
Stream size : 13.7 MiB (29%)
Writing application : Lavc55.17.100
Writing library : libVorbis (Schaufenugget) (20101101 (Schaufenugget))
Language : English
Default : Yes
Forced : No

Code:

https://www.classcentral.com/course/virology2-1537